Metal-free glycosylation with glycosyl fluorides in liquid SO₂

• Krista Gulbe,
• Jevgeņija Lugiņina,
• Edijs Jansons,
• Artis Kinens and
• Māris Turks

Beilstein J. Org. Chem. 2021, 17, 964–976, doi:10.3762/bjoc.17.78

• equilibrium. Keywords: fluorosulfite; glycosyl fluoride; Lewis acid; liquid sulfur dioxide; metal-free glycosylation; Introduction The glycosylation reaction is still one of the most important and basic synthetic strategies in carbohydrate chemistry that provides access to the various types of

• not possess the participating group at C2 position, still react through the oxocarbenium ion intermediate. Conclusion In summary, novel sulfur dioxide-assisted and metal-free glycosylation conditions by employing a combination of glycosyl fluoride as the glycosyl donor and liquid SO2 as both solvent